A field publish last calendar week in the journalBiofabricationdescribes a raw technique to build alternate for damaged three dimensional human tissues . The researchers running the study are try out to make an myringa . But their technique , if successful , might also one day create replacements for complex reproductive tissues .
Many of the tissues in your consistency carry strands of a inviolable molecule called collagen that is lay down by cubicle called fibroblasts . In some tissue , collagen fibers forge a more - or - less random mat . But in others , specially tissues that resist or redistribute force – such as tendons or ( as it happens ) eardrums , the strands of collagen are arranged in accurate patterns that channel forces in specific focal point . We do n’t yet completely understand how the fibroblasts build these complex structures , and when these tissue paper are damaged by hurt or disease , the fibers do n’t always grow back in the right pattern . The end result ? marred tissue paper that do n’t work out as well as they used to .
In the subject field , Serena Danti of the University of Twente and colleagues from the University of Pisa , Maastricht University , and the Scuola Superiore Sant’Anna , used linear 3D printing methods to lay down a thin scaffold that mimicked the three dimensional traffic pattern of collagen fibers inside the eardrum . They seeded their print with human stem cells that can produce fibroblast , and find that the cell could successfully grow on the fiber in the scaffold . Their next pace , harmonize to Danti , is to see whether they can get the cells to differentiate and produce collagen that match the scaffold . It ’s a first step toward making a fully running successor eardrum out of human tissue , and toward finally creating tissues with more complex 3D collagen meshing .
Two other super functional tissue paper that swear on 3D collagen fibre internet ? cervix and the cavernous tissue inside the member . Damage to either tissue can have serious effects on their ability to do their jobs . Tears in penile cavernous tissuecan jumper lead to impotence . harm to cervical tissue can lead to an increase risk of infection of stillbirth or preterm parentage . It ’s not hard to see that better proficiency to repair them could be a freehanded deal .
[ source : Aspden 1988 ; Kelly 1997;Mota et al . 2015 ]
3D printingMedicinetissue engineering
Daily Newsletter
Get the skilful tech , science , and culture news in your inbox day by day .
News from the futurity , save to your nowadays .
You May Also Like
